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标题：ANTIGEN-INDUCED DECREASE OF SALICYLIC ACID ABSORPTION FROM THE SMALL INTESTINE IN ACTIVELY IMMUNIZED RATS
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作者：JUNZO NAKAMURA ; AKIRA YAMAMOTO ; SHIGEYUKI TAKADA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1982
卷号：5
期号：4
页码：278-284
DOI：10.1248/bpb1978.5.278
出版社：The Pharmaceutical Society of Japan
摘要：Rats were intraperitoneally immunized with bovine γ-globulin (BGG) emulsified in incomplete Freund's adjuvant. Intestinal absorption of salicylic acid from the rat small intestine was examined by means of in situ recirculation technique. The disappearance of salicylic acid from the luminal solution was significantly decreased in rats challenged intravenously with BGG compared to saline as control. A significant decrease in absorption of salicylic acid was noted in rats immunized twice and three times, but not in rats immunized only once. The effect was maintained for at least 5 weeks after the third immunization, whereas it disappeared within 10 weeks. In normal rats, the decreased absorption of salicylic acid by the intravenous challenge with BGG was hardly observed at all. These findings suggest that the intestinal absorption of salicylic acid may be affected by systemic anaphylaxis in actively immunized rats.
关键词：in situ recirculation technique