文章基本信息

标题：EFFECT OF 1-m-TOLUENEAZO-2-NAPHTHOL ON HEPATIC DRUG METABOLISM. II. INDUCTION OF UDP-GLUCURONYLTRANSFERASE
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作者：SHIGERU ADACHI ; SHOICHI FUJITA ; TAKASHI UESUGI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1982
卷号：5
期号：4
页码：273-277
DOI：10.1248/bpb1978.5.273
出版社：The Pharmaceutical Society of Japan
摘要：Effect of a potent cytochrome P-448 inducer, 1-m-tolueneazo-2-naphthol (m-TAN) on hepatic microsomal UDP-glucuronyl-transferase (UDPGT) activity was studied. The UDPGT activity reached the maximum level on the fifth day after either a single injection or consecutive daily administrations. The UDPGT activities towards p-nitrophenol, 1-naphthol and chloramphenicol were increased up to 6, 2.5 and 1.8 folds of control levels respectively, in microsomes from m-TAN treated rats. 3-Methylcholanthrene, on the other hand, caused 4 and 2 fold increase in UDPGT activities towards p-nitrophenol and 1-naphthol respectively, but did not cause significant increase in UDPGT activity towards chloramphenicol. It is concluded that m-TAN is a new, potent inducer of UDPGT activity with its potency exceeding that of 3-methylcholanthrene and the pattern of induction, a little different from that of 3-methylcholanthrene.
关键词：3-methylcholanthrene