文章基本信息

标题：INDUCTION OF A DELAYED TYPE HYPERSENSITIVITY TO CARRAGEENIN IN MICE
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作者：SHIN YOSHINO ; KAZUO OHUCHI ; SUSUMU TSURUFUJI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1982
卷号：5
期号：4
页码：266-272
DOI：10.1248/bpb1978.5.266
出版社：The Pharmaceutical Society of Japan
摘要：Induction of a delayed type hypersensitivity to carrageenin in mice was investigated with successful results. Male ddY/s mice were immunized with 1 mg of carrageenin in 100μl of Freund's complete adjuvant-saline (1 : 1) emulsion and challenged 10d after the immunization on their footpads with either 10 or 40μg of the antigen in 2.5μl of Freund's incomplete adjuvant-saline (1 : 1) emulsion. The mice exhibited a strong allergic footpad reaction at 24-48h after the challenge injection. The footpad reaction was successfully transferred with spleen cells. Non-steroidal antiinflammatory drug, indomethacin, and steroidal antiinflammatory drug, dexamethasone, suppressed the delayed type hypersensitivity reaction.
关键词：indomethacin