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  • 标题:STRUCTURE-ACTIVITY STUDIES OF SOME OLEANANE TRITERPENOID GLYCOSIDES AND THEIR RELATED COMPOUNDS FROM THE LEAVES OF TETRAPANAX PAPYRIFERUM ON ANTI-INFLAMMATORY ACTIVITIES
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  • 作者:ETSUKO SUGISHITA ; SAKAE AMAGAYA ; YUKIO OGIHARA
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1982
  • 卷号:5
  • 期号:6
  • 页码:379-387
  • DOI:10.1248/bpb1978.5.379
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The anti-inflammatory activities of oleanane triterpenoid glycosides, papyrioside L-IIa, L-IIb, L-IIc and L-IId, extracted from Tetrapanax papyriferum (Araliaceae), and their aglycones, papyriogenin A and C and propapyriogenin A1 and A2, were investigated by using the carrageenin-induced edema and the cotton pellet granuloma tests in mice. Of these compounds, papyriogenin A and C (30 mg/kg p.o.) manifested in these tests almost the same potency as prednisolone (25 mg/kg p.o.). The structure-activity relationships of these and related triterpenes have been investigated. This takes into account particularly variation in the oxygen function and the molecular conformation. We have found that the anti-inflammatory activity of these triterpenes was favoured when the molecules tended to take a planar conformation ; this was induced by the heteroanulardiene group between C and D ring.
  • 关键词:glycyrrhetinic acid
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