文章基本信息

标题：PREDICTION OF RENAL TUBULAR SECRETION OF TETRAETHYLAMMONIUM BROMIDE BY USE OF ENDOGENOUS N1-METHYLNICOTINAMIDE IN THE RAT
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作者：CHANG KOO SHIM ; YASUFUMI SAWADA ; TATSUJI IGA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1982
卷号：5
期号：7
页码：534-537
DOI：10.1248/bpb1978.5.534
出版社：The Pharmaceutical Society of Japan
摘要：The renal secretion of an endogenous N¹-methylnicotinamide (NMN) and its usefulness as an index of the renal secretion clearance of tetraethylammonium bromide (TEA), a representative organic cationic drug, was examined in the rats treated with folic acid, glycerol and uranyl nitrate, respectively. There was a statistically significant correlation between the renal secretion clearance of TEA and that of NMN in the intact and acute renal failure rats (r=0.969, p<0.001). It was suggested that the renal secretion clearance of the endogenous NMN could be used as an index to assess the renal tubular function for the secretion of organic cationic drugs like TEA.
关键词：uranyl nitrate