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标题：EFFECTS OF A HYPOGLYCEMIC COMPONENT OF GINSENG RADIX ON INSULIN BIOSYNTHESIS IN NORMAL AND DIABETIC ANIMALS
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作者：ISAMI WAKI ; HITONOBU KYO ; MASATOSHI YASUDA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1982
卷号：5
期号：8
页码：547-554
DOI：10.1248/bpb1978.5.547
出版社：The Pharmaceutical Society of Japan
摘要：DPG-3-2, a component of ginseng radix, which lowers the blood glucose level and stimulates insulin release in diabetic animals, was studied for its effects on insulin biosynthesis in different preparations of pancreas from animals with normoglycemia and with hyperglycemia (alloxan diabetic rats and genetically diabetic mice, KK-CA^y). We measured incorporation of radioactive leucine into insulin and other protein fractions during a 2-h perfusion of rat pancreas, and into insulin during a 3-h incubation of mouse islets. Biosynthesis of insulin during a long-term culture of islets from KK-CA^y mice was also measured. DPG-3-2 was found practically not to increase the incorporation into insulin in the pancreatic preparations from animals with normoglycemia, but in such preparations from animals with hyperglycemia DPG-3-2 (0.2-1.0 mg/ml caused 1.5-1.8-fold incorporation into insulin. In addition, a long-term treatment of DPG-3-2 (0.5 mg/ml) was shown to stimulate insulin biosyntesis in islets from KK-CA^y mice. Ginsenoside-Rb₁ and -Rg₁ decreased the insulin content of islet to the undetectable level. Thus, DPG-3-2 was shown to stimulate insulin biosynthesis in different preparations of pancreas from animals with hyperglycemia.
关键词：ginsenoside