文章基本信息

标题：CYCLODEXTRIN-INDUCED HEMOLYSIS AND SHAPE CHANGES OF HUMAN ERYTHROCYTES IN VITRO
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作者：TETSUMI IRIE ; MASAKI OTAGIRI ; MIKI SUNADA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1982
卷号：5
期号：9
页码：741-744
DOI：10.1248/bpb1978.5.741
出版社：The Pharmaceutical Society of Japan
摘要：Cyclodextrins (CyDs) at higher concentrations were found to cause hemolysis of human erythrocytes in the order of β->α->γ-CyD in isotonic solution. Biphasic effects of CyDs were observed for the osmotic and heat-induced hemolysis; i.e. the protection at relatively low CyD concentrations and stimulation at higher CyD concentrations. From the scanning electron microscopic observations, CyDs induced shape changes of membrane internalization type on erythrocytes. CyDs caused the release of cholesterol from erychrocyte membrane in the order of β->γ->α-CyD. These results dearly indicate that CyD-induced hemolysis is probably a secondary event resulting from the membrane disruption which elicited the removal of membrane components from erythrocytes.
关键词：release of cholesterol