文章基本信息

标题：MOTOR DYSFUNCTION IN SPONTANEOUS THYMOMA RATS, BUFFALO/MNA
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作者：FUMINORI KATO ; MINORU WATANABE
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1982
卷号：5
期号：9
页码：727-733
DOI：10.1248/bpb1978.5.727
出版社：The Pharmaceutical Society of Japan
摘要：The muscle responsiveness of rats of Buffalo/Mna strain with spontaneous thymoma (Mna rats) was investigated in vivo electrophysiologically and pharmacologically in order to determine the principal cause of the muscle weakness and fatigability. Hindlimb muscles of these rats exhibited a lesser contractility and a greater fatigability during repecitive nerve stimulation than those of rats of another strain, ACI. Nevertheless, there was no difference in the time course of amplitude of evoked electromyograms between Mna and ACI rats. According to the test of drug sensitivity, Mna rats were much less sensitive to curare than ACI rats. Sensitivity to 4-aminopyridine was normal. In conclusion, Mna rats showed an increased fatigability and weakness of the muscle. The principal cause seems to be involved in contractile mechanisms subsequent to muscle cell membrane. The reduced sensitivity to curare suggests a possibility of change some at the site of neuro-muscular junction.
关键词：d-tubocurarine subsensitivity