文章基本信息

标题：A MODE OF ACTION OF MORPHINE ON A QUICKLY LEARNED CONDITIONED SUPPRESSION IN MICE
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作者：TSUTOMU KAMEYAMA ; MITSUAKI NAGASAKA
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1984
卷号：7
期号：3
页码：151-155
DOI：10.1248/bpb1978.7.151
出版社：The Pharmaceutical Society of Japan
摘要：Mice exhibited marked suppression of motor activity when placed in the same environment where they had previously received electric shocks. Morphine-HCl (20 mg/kg) markedly attenuated such a conditioned suppression in mice. The morphine-induced reduction of the conditioned suppression was antagonized by pretreatment with reserpine (0.1 and 0.5 mg/kg), haloperiodol, pimozide and α-methyl-p-tyrosine, but not atropine-sulfate, p-chlorophenylalanine, phenoxybenzamine-HCl or propranolol. Thus, it is possible that the potentiation of the dopaminergic neurotransmission in the brain is involved in the morphine-induced reduction of the conditioned suppression in mice.
关键词：mice