文章基本信息

标题：CHANGES IN FUNCTIONAL CERULOPLASMIN CONCENTRATIONS OF PLASMA AND EXUDATE AND THE EFFECT OF EXOGENOUS CERULOPLASMIN ON THE CARRAGEENIN-INDUCED INFLAMMATION IN RATS
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作者：HIDEO NAKAGAWA ; KAZUO SUZUKI ; KOHJI YAMAKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1984
卷号：7
期号：10
页码：755-759
DOI：10.1248/bpb1978.7.755
出版社：The Pharmaceutical Society of Japan
摘要：Changes in functional ceruloplasmin (Cp) concentrations of plasma and exudate during acute and chronic inflammatory processes were studied in detail by measuring Cp oxidase activity in the carrageenin-induced inflammation in rats. In contrast with the plasma functional Cp level as an acute-phase reactant, the exudate functional Cp level was very low during the acute phase, increased in the chronic phase and reached a constant value which was only half value of the plasma functional Cp level. The locally injected Cp had no effect on the carrageenin-induced inflammation, suggesting that exogenous Cp has no anti-inflammatory effect on the inflamed rats eating normal diet.
关键词：steroidal anti-inflammatory drug