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标题：THE STUDIES ON THE ROLE OF GASTRIC GLYCOPROTEINS WITH REFERENCE TO CYTOPROTECTION : PROTECTIVE EFFECT OF PROSTAGLANDIN E2 AND SOFALCONE ON ETHANOL-INDUCED NECROSIS
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作者：NOBORU FUJIMOTO ; SHIGERU MURAKAMI ; TOSHIO SUWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1984
卷号：7
期号：11
页码：864-871
DOI：10.1248/bpb1978.7.864
出版社：The Pharmaceutical Society of Japan
摘要：The gastric cytoprotective action of prostaglandin E₂ (PGE₂) and sofalcone was studied in rats. The in vitro incorporating activity of ³H-glucosamine into the gastric macromolecular glycoproteins was examined when PGE₂ (0.1 mg/kg, p.o.) or sofalcone (100 mg/kg, i.p.) was administered 5, 15 or 30 min before the oral administration of absolute ethanol. The cytoprotective effect of PGE₂ against gastric mucosal damage was demonstrated 5 min after PGE₂ was given orally. The cytoprotective effect by sofalcone was seen after 15 min. However, during this period, the decrease in gastric macromolecular glycoprotein synthesis induced by the ethanol damage could not be restored by pretreatment with PGE₂ or sofalcone. On the other hand, the reduction in the content of the gastric macromolecular glycoproteins by the ethanol damage was found to be prevented to a significant extent by pretreatment with PGE₂. The same phenomenon was also observed in the administration of sofalcone. Accordingly, PGE₂ has stimulating effect on the gastric glycoproteins biosynthesis, but this effect can not be considered as the mechanism responsible for cytoprotection, if indeed a single mechanism exists. Thus, it is suggested that the adhesion or maintenance of secreted macromolecular glycoproteins to the gastric tissue is closely related to cytoprotection.
关键词：sofalcone