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标题：BIOPHARMACEUTICAL EVALUATION OF METHYLCELLULOSE AS AN EXCIPIENT FOR NITROGLYCERIN TABLETS
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作者：FUMINORI SHIBUYA ; KAYO KURAMOTO ; HAJIME KOIZUMI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1985
卷号：8
期号：5
页码：352-356
DOI：10.1248/bpb1978.8.352
出版社：The Pharmaceutical Society of Japan
摘要：To examine the bioavailability of nitroglycerin in sublingual tablet, 5 healthy adult volunteers underwent simultaneous sublingual administration of a table prepared with methylcellulose and a tablet prepared with lactose containing 0.15 mg of nitroglycerin and 0.15 mg of nitroglycerin-¹⁵N₃, respectively. In 4 of 5 volunteers, no difference in plasma concentration determined by gas chromatography-mass spectrometry (GC-MS) was observed between 2 tablets described above, so it was well accepted that nitroglycerin in tablets prepared with methylcellulose had a similar bioavailability to that in tablets prepared with lactose. The simultaneous administration of the 2 nitroglycerin tablets to a healthy volunteer, one of which containing the drug labeled with a stable isotope followed by GC-MS assay, seems to be the most suitable method for a precise comparison of bioavailability of the formulations.
关键词：plasma concentration