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标题：PHARMACOLOGICAL STUDIES OF FURO [3, 2-b] INDOLE DERIVATIVES. I. ANALGESIC, ANTI-PYRETIC AND ANTI-INLAMMATORY EFFECTS OF FI-302, N-(3-PIPERIDINOPROPYL)-4-METHYL-6-TRIFLUOROMETHYL-FURO [3, 2-b] INDOLE-2-CARBOXAMIDE, IN EXPERIMENTAL ANIMALS
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作者：TSUTOMU KAMEYAMA ; FUSAO AMANUMA ; SHIGERU OKUYAMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1985
卷号：8
期号：6
页码：477-486
DOI：10.1248/bpb1978.8.477
出版社：The Pharmaceutical Society of Japan
摘要：The analgesic, anti-pyretic and anti-inflammatory effects of FI-302, N-(3-piperidinopropyl)-4-methyl-6-trifluoromethyl-furo [3, 2-b] indole-2-carboxamide, a newly synthesized tricyclic compound, were investigated in comparison with those of nonsteroidal anti-inflammatory drugs (NSAIDs). FI-302 showed potent analgesic and anti-pyretic effects in the various models used. FI-302 showed an inhibitory effect on acute inflammatory response such as carrageenin-induced edema, but did not show any effect on chronic inflammatory response such as cotton pellet granuloma. These effects of FI-302 were about 2 to 7 times more potent than those of non-acidic NSAIDs such as mepirizole and tiaramide. Moreover, FI-302 had little or no ulcerogenic activity. From these results, it is conceivable that the spectrum of FI-302's activities is similar to those of nn-acidic NSAIDs such as mepirizole and tiaramide. These results suggest that FI-302 is a new non-ulcerogenic anti-inflammatory compound, and should be suitably applicable for clinical purposes.
关键词：ulcerogenic activity