文章基本信息

标题：HYPOLIPIDEMIC EFFECTS OF DIETARY 7-OXO-24, 25-DIHYDROLANOSTEROL
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作者：YOSHIKO SONODA ; YOSHIHIRO SATO
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1985
卷号：8
期号：7
页码：518-524
DOI：10.1248/bpb1978.8.518
出版社：The Pharmaceutical Society of Japan
摘要：7-Oxo-24, 25-dihydrolanosterol (7-oxo-DHL), an ihibitor of cholesterol biosynthesis from lanosterol in vitro, lowered the serum total-cholesterol and triglyceride at a level of 0.1% in a diet on male Wistar rats. This effect was slightly lower than that of clofi-brate (CF) which was examined as a reference. Further, the reduction in serum totalcholesterol levels were associated with a slight reduction in the levels of high density lipoprotein (HDL) cholesterol, resulting in a decrease in the atherogenic index. The rate of decrease of liver total-cholesterol by 7-oxo-DHL was higher than that of CF soon after taking off the diet. Although CF produced a marked increase of liver size, no significant increase was observed in the rats fed with 7-oxo-DHL. The effects of 7-oxo-DHL in the rats fed with 3% cholesterol in a diet were examined and compared with that of control. These results strongly suggest that 7-oxo-DHL is considerably hypolipidemic in rats.
关键词：triglyceride