文章基本信息

标题：IDENTIFICATION OF MENAQUINONE-4 METABOLITES IN THE RAT
本地全文：下载
作者：Kyoichi TADANO ; Teruaki YUZURIHA ; Tadashi SATO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1989
卷号：12
期号：10
页码：640-645
DOI：10.1248/bpb1978.12.640
出版社：The Pharmaceutical Society of Japan
摘要：Four metabolites of menaquinone-4 [MQ-4] were isolated from rat urine, bile and liver. From rat urine following intravenous or oral administration of [¹⁴C] MQ-4, two major metabolites were isolated and their aglycones were identified as 2-methyl-3-(5'-carboxy-3'-methyl-2'-pentyl)-1, 4-naphthoquinone [K acid 1] and 3-(3'-carboxybutyl)-2-methyl-1, 4-naphthoquinone [K acid 2]. The aglycone of a third minor metabolite isolated from bile was tentatively identified as 2-methyl-3-(15'-carboxy-3', 7', 11'-trimethyl-2', 6', 10', 14'-hexadecatetranyl)-1, 4-naphthoquinone [MQ-4-COOH]. The structures of the three aglycones, which were excreted into the urine or bile mainly as glucuronide conjugates, indicated that oxidative degradation of the alkyl side chain of MQ-4 had occurred by ω-and β-oxidation. In addition, 2, 3-epoxy-MQ-4 was identified in the liver of rats which were pretreated with warfarin and then dosed with [¹⁴C] MQ-4.
关键词：metabolite