文章基本信息

标题：The Effect of Bile Salts on the Oral Mucosal Absorption of Human Calcitonin in Rats
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作者：Yuichiro NAKADA ; Norio AWATA ; Yoshimi IKUTA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1989
卷号：12
期号：12
页码：736-743
DOI：10.1248/bpb1978.12.736
出版社：The Pharmaceutical Society of Japan
摘要：The relationship between the inhibition of the degradation of human calcitonin (HCT) in the supernatant of the rat's oral mucosa homogenate and the promoting effect on the rat's oral mucosal absorption of HCT was investigated by using ten kinds of sodium bile salts. The promoting effects and the inhibition of the degradation by the dihydroxy bile salts were related to the hydrophobicity, respectively. The inhibition of the degradation of HCT was related to the promoting effect on the oral mucosal absorption of HCT in the presense of the dihydroxy bile salts and to the concentration of the bile salts. Furthermore, the micelle formed by the bile salts would be concerned with the inhibition of the degradation of HCT.
关键词：micelle