文章基本信息

标题：Effects of Calclium Channel Blockers and Hydralazine on Epinephrine-Induced Stimulation of Glucose Output from Primary Cultured Rat Hepatocytes
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作者：Katsuyoshi SUNAGA ; Masahiko OGIHARA
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1990
卷号：13
期号：11
页码：653-658
DOI：10.1248/bpb1978.13.653
出版社：The Pharmaceutical Society of Japan
摘要：Effects of calcium channel blockers from structurally different classes and hydralazine on epinephrine-induced stimulation of glucose output from primary cultured rat hepatocytes were examined in vitro. Diltiazem, verapamil, and nifedipine dose-dependently inhibited the epinephrine-induced stimulation of glucose output from the primary cultured rat hepatocytes. In contrast to these agents, nicardipine caused decreases in the basal and epinephrine-stimulated glucose output from rat hepatocytes in primary culture. Hydralazine treatment was found to reduce the response in a dose-dependent manner. These results indicate that the calcium channel blockers and hydralazine did not potentiate but reduce the epinephrine-induced stimulation of glucose output from primary cultures of rat hepatocytes in vitro.
关键词：hydralazine