文章基本信息

标题：Hepatic Drug Metabolizing Activity in Rats with Carrageenan-Induced Inflammation
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作者：Masaaki ISHIKAWA ; Kenroh SASAKI ; Masayasu OZAKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1991
卷号：14
期号：3
页码：132-138
DOI：10.1248/bpb1978.14.132
出版社：The Pharmaceutical Society of Japan
摘要：Effect of carrageenan-induced inflammation on hepatic drug metabolism was studied in male and female Wistar rats. One day after treatment of male and female Wistar rats with carrageenan (1%, 0.1 ml, s.c.) (i) a prolongation of the duration of sleeping time induced by hexobarbital (100 mg/kg, i.p.), (ii) decreases biotransformation of hexobarbital, aminopyrine and ethylmorphine in the hepatic 9000×g supernatants (S-9) and (iii) a decrease in cytochrome P-450 content were observed in males but not female rats. However, carrageenan treatment did not alter aniline hydroxylase activity in animals of either sex. Carrageenan also suppressed induction of hexobarbital, aminopyrine and ethylmorphine metabolism by phenobarbital treatment, and depressed the induction of hepatic S-9 cytochrome P-450 content caused by phenobarbital treatment. These data show that there is a sex-related difference in the ability of carrageenan to alter hepatic drug metabolism, which is substrate-specific, in the rats.