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标题：Effects of KF-14363 on Liver Fibrosis in Rats with Chronic Liver Injury Induced by Carbon Tetrachloride
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作者：Ikufumi YOSHITAKE ; Eiko OHISHI ; Junichi SANO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1991
卷号：14
期号：12
页码：679-685
DOI：10.1248/bpb1978.14.679
出版社：The Pharmaceutical Society of Japan
摘要：The present study examined the effects of (1-[(2-thiazolin-2-yl) amino]-acetyl-4-(1, 3-dithiol-2-ylidene)-2, 3, 4, 5-tetrahydro-1H-1-benzazepin-3, 5-dione hydrochloride (KF-14363) on liver fibrosis in rats with chronic liver injury induced by carbon tetrachloride (CCl₄). Liver injury in male rats was induced by repeated administration of CCl₄ at 0.5 ml/kg twice a week. The progression of liver fibrosis was checked in the 4th, 6th, 8th and 10th weeks using the relative amount of hepatic 4-hydroxy proline (4-hyp) to total proteine as an index of hepatic collagen. The relative amount of hepatic 4-hyp in these rats exceeded significantly that in rats not administered CCl₄ by the 4th week. This progressed in proportion to the duration of CCl₄ administration. In groups concurrently administered KF-14363 at 30 and 100 mg/kg/d from the 5th or 8th week of the CCl₄ administration, the relative amount of hepatic 4-hyp was found to be lower in the 10th week than at the start of the KF-14363 administration. The inhibition of liver fibrosis was also observed histopathologically. The concurrently co-administration with CCl₄ or KF-14363 at 30 and 100 mg/kg for 2 or 5 weeks inhibited the increases in serum transaminases and alkaline phosphatase induced by CCl₄. The results show that KF-14363 inhibits liver fibrosis in a dose dependent fashion in rats with progressive liver injury.
关键词：carbon tetrachloride