文章基本信息

标题：YM-14673, a New Thyrotropin-Releasing Hormone Analog, Augments Long-Term Potentiation in the Mossy Fiber-CA3 System of Guinea Pig Hippocampal Slices
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作者：Kumatoshi ISHIHARA ; Hiroshi KATSUKI ; Masunobu SUGIMURA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1992
卷号：15
期号：2
页码：75-78
DOI：10.1248/bpb1978.15.75
出版社：The Pharmaceutical Society of Japan
摘要：Effects of a new thyrotropin-releasing hormone (TRH) analog, N^α-[[(S)-4-oxo-2-azetidinyl] carbonyl] L-histidyl-L-prolinamide dihydrate (YM-14673), which improves experimentally induced memory dysfunction, on long-term potentiation (LTP) in the mossy fiber-CA3 system, were investigated using guinea pig hippocampal slices. At concentrations of 10^-7 M and 10^-6M, YM-14673 significantly augmented LTP in a concentration dependent manner. The magnitude of effect of 10^-6M YM-14673 was similar to that of 10^-6M TRH. As LTP in the hippocampus is regarded as an elementary process of memory and learning, the augmenting effect of YM-14673 on LTP in the present study may contribute to this drug's ability to remedy memory dysfunction.