文章基本信息

标题：TRANS-PROSTAGLANDIN E2 ENHANCES FIBRINOLYSIS
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作者：Tsutomu URANO ; Mari SHIMOKAWA ; Toshio KINOSHITA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1992
卷号：15
期号：5
页码：261-265
DOI：10.1248/bpb1978.15.261
出版社：The Pharmaceutical Society of Japan
摘要：5, 6-trans-Prostaglandin E₂ (trans-PG E₂) was found to accelerate the fibrinolysis in a cell-free system. trans-PG E₂ decreased the lysis time by 15% in the fibrin clot lysis time method and increased the lysis area by 22% in the fibrin plate method. On the contrary, 5, 6-cis-prostaglandin E₂ did not have such effects. trans-PG E₂ did not exert the effect in the absence of either tissue-plasminogen activator or plasminogen. These results suggest that trans-PG E₂ enhances the generation of plasmin from plasminogen by tissue-plasminogen activator.
关键词：fibrinolysis, enhancement