文章基本信息

标题：EFFECT OF DIISOPROPYL 1, 3-DITHIOL-2-YLIDENEMALONATE ON MICROSOMAL ELECTRON TRANSPORT SYSTEM IN RAT LIVER
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作者：MINORU KATOH ; MITSUKAZU KITADA ; TETSUO SATOH 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1980
卷号：3
期号：5
页码：261-263
DOI：10.1248/bpb1978.3.261
出版社：The Pharmaceutical Society of Japan
摘要：Effect of diisopropyl 1, 3-dithiol-2-ylidenemalonate (NKK-105) on the components of rat liver microsomal electron transport system was investigated by comparison with those of phenobarbital, 3-methylcholanthrene and polychlorinated biphenyl. When NKK-105 was administered to rats at a dose of 250 mg/kg/day for 7 days, cytochrome b₅ content and NADPH-cytochrome c reductase activity were significantly increased but cytochrome P-450 content to the lesser extent. Three inducers of the drug metabolizing enzymes remarkably increased cytochrome P-450 content but increased cytochrome b₅ content to a lesser extent.
关键词：NADPH-cytochrome c reductase