文章基本信息

标题：MECHANISM OF RENAL DISTRIBUTION OF AMINOGLYCOSIDE ANTIBIOTICS
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作者：IZUMI KOMIYA ; KOSHIRO UMEMURA ; MASATAKA FUJITA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1980
卷号：3
期号：6
页码：299-308
DOI：10.1248/bpb1978.3.299
出版社：The Pharmaceutical Society of Japan
摘要：The renal accumulation of dibekacin, one of the aminoglycoside antibiotics, was pharmacokinetically analyzed and the mechanism of the renal accumulation of these antibiotics was investigated. The remaining amounts of dibekacin in the kidneys were adequately expressed by the bi-exponential equation. There was no possibility of a covalent bond between dibekacin and the renal tissue components. The renal accumulation of the aminoglycoside antibiotics was explained in terms of the two successive processes, renal tubular reabsorption and electrostatic interaction between these antibiotics and the tissue components. In other words, these antibiotics were reabsorbed at the renal tubules and transported into renal tubular epithelial cells and bound to the tissue components by electrostatic force. The electrostatic interaction also played an important role in increasing the acute toxicities of aminoglycoside antibiotics.
关键词：pharmacokinetics