文章基本信息

标题：ANTI-INFLAMMATORY TESTING METHODS : COMPARATIVE EVALUATION OF MICE AND RATS
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作者：ETSUKO SUGISHITA ; SAKAE AMAGAYA ; YUKIO OGIHARA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：8
页码：565-575
DOI：10.1248/bpb1978.4.565
出版社：The Pharmaceutical Society of Japan
摘要：The possibility of using mice in place of rats on the anti-inflammatory screening tests was investigated. The diversities of the responses between mice and rats on screening tests, that is, carrageenin, formalin-induced edema in the hind paw, adjuvant arthritis and cotton peller granuloma were observed with p.o. administration of prednisolone, 0.5 mg/kg and 5.0 mg/kg, and indomethacin, 0.5 mg/kg and 5.0 mg/kg. On the effects of these drugs on screening tests, a similar type of phenomena between rats and mice was found. Then the dose-response relationships of aspirin, flufenamic acid, phenylbutazone, cyproheptadine, prednisolone and indomethacin were examined in four kinds of screening tests mentioned above. Prednisolone, indomethacin, phenylbutazone and aspirin inhibited the carrageenin, formalin-induced edema, cotton pellet granuloma and adjuvant arthritis apparently, but flufenamic acid showed no inhibition on the carrageenin and formalininduced edema. Cyproheptadine inhibited the formalin and serotonin-induced edema. We have found that mice, instead of rats, can be used for the anti-inflammatory screening methods.
关键词：indomethacin