文章基本信息

标题：HISTAMINE RECEPTORS IN THE BRONCHIAL MUSCULATURE AND VASCULATURE OF THE DOG
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作者：SAIZO YANAURA ; TOMOKAZU HOSOKAWA ; KAZUHIRO GOTO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：9
页码：685-690
DOI：10.1248/bpb1978.4.685
出版社：The Pharmaceutical Society of Japan
摘要：Participation of histamine H₁-and H₂-receptors in the bronchial musculature and vasculature of the dog was investigated by using the method for evaluating airway responses. A peristaltic pump and a Starling pneumatic resistance were used for a constant pressure perfusion. Dogs given 0.1-10μg histamine by a close intraarterial injection showed increases in ventilation overflow (bronchoconstriction) and in blood flow (bronchial vasodilatation) in a dose-dependent manner. The bronchoconstriction produced by histamine was antagonized strongly by chlorpheniramine, a H₁-receptor antagonist, but not modified by cimetidine, a H₂-receptor antagonist. The bronchial vasodilatation produced by histamine was antagonized by both chlorpheniramine and cimetidine. These results suggest that histamine evokes bronchoconstriction through H₁-receptors and bronchial vasodilatation through H₁-and H₂-receptors.
关键词：bronchial vasculature