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标题：EFFECTS OF AGE AND SEX ON MICROSOMAL HEME OXYGENASE AND CYTOCHROME P-450 CONTENT IN LIVER OF RATS
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作者：TOSHIHIKO ARIYOSHI ; KAZUMITSU TSUBOI ; KAZUHISA HAMASAKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：9
页码：664-669
DOI：10.1248/bpb1978.4.664
出版社：The Pharmaceutical Society of Japan
摘要：Effects of age and sex on microsomal heme oxygenase activity and cytochrome P-450 content were investigated in Wistar rats. heme oxygenase activity declined with an increase in age, namely, its activity in 100 days old (young) rats was 58% in male and 72% in female rats as compared with respective 30 days old (immature) rats, and in 300 days old (old) rats it was 32% in male and 39% in female rats. In male rats, cytochrome P-450 content based on 100 g body weight decreased only in old rats as compared with immature rats, whereas a significant reduction was observed in female rats in the content based on mg microsomal protein as well as based on 100 g body weight in young and old animals. In littermate rats at the age of 56 days which obtained by inbreeding in our laboratory, sex difference was apparent in heme oxygenase activity and cytochrome P-450 content, and further a good reciprocal correlation between that activity and content (r=-0.9730 in male, and r=-0.8252 in female) was observed.
关键词：heme degradation