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标题：DIFFERENCE BETWEEN MAGNESIUM AND MANGANESE IONS IN MODIFICATION OF EFFECT OF CATECHOLAMINE ON ADENYLATE CYCLASE SYSTEM IN EHRLICH ASCITES TUMOR CELLS
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作者：TOMONORI KUROKAWA ; YOKO KITAMURA ; MIDORI MORIUCHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：10
页码：794-797
DOI：10.1248/bpb1978.4.794
出版社：The Pharmaceutical Society of Japan
摘要：Involvement of divalent cations was examined in the activation of catecholaminesensitive adenylate cyclase in Ehrlich ascites tumor cells. In the presence of various concentrations of either Mg²⁺ or Mn²⁺, both basal and norepinephrine-stimulated adenylate cyclase activities were measured. Both activities were gradually increased with the increase in Mg²⁺ concentration. On the other hand, with Mn²⁺, both activities were maximum at the low (2.5mM) concentration, and decreased at the higher concentrations, the decrease being marked in the norepinephrine-stimulated activity. Similar difference between the two divalent cations was also observed in the effect on the binding of the β-adrenergic ligand to the membrane receptor.
关键词：Ehrlich ascites tumor cells