文章基本信息

标题：EFFECTS OF INTRACEREBRAL ADMINISTRATION OF ATROPINE AND MORPHINE ON THE CAUDATE STIMULATION-INDUCED CAUDATE SPINDLE IN RATS
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作者：KATSUO KAMATA ; HIROMOTO AOKI ; TSUTOMU KAMEYAMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：10
页码：788-793
DOI：10.1248/bpb1978.4.788
出版社：The Pharmaceutical Society of Japan
摘要：The electrical stimulation of the caudate nucleus could induce a caudate spindle in the rat as in case of the cat and monkey. The spindle was enhanced by atropine (3-10 mg/kg, i.v.) or morphine (3-10 mg/kg, i.v.), and the effects of these drugs were completely abolished by eserine (0.3 mg/kg, i.v.), but not by methysergide (1 mg/kg, i.v.), PCPA (400 mg/kg, i.p. for 3 days) or reserpine (3 mg/kg, i.p. for 2 days). An intraventricular injection of atropine (5-10 μg/rat) or morphine (10 μg/rat) exerted a facilitatory action on the spindle, while an intrathalamic and intracaudate injection of atropine (5-50 μg/rat) showed a suppressive action. The spindle was also markedly enhanced by the microinjection of atropine (15-30 μg/rat) or morphine (30 μg/rat) into the reticular formation, and these actions were completely antagonized by eserine (0.3 mg/kg, i.v.), but only partially by methysergide (4 μg/rat, intraventricular administration.) These results suggest that the cholinergic system may play an important role in the regulation of the caudate spindle.