文章基本信息

标题：A NOTE ON SATURABLE AND INHIBITORY KINETICS OF p-AMINOHIPPURATE RENAL TRANSPORT IN RABBITS
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作者：KATSUTOSHI KOSHI ; YOKO SHIRAI ; KAZUNORI KATAYAMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1983
卷号：6
期号：3
页码：161-169
DOI：10.1248/bpb1978.6.161
出版社：The Pharmaceutical Society of Japan
摘要：In order to establish quantitative expressions of inhibitory kinetics in renal tubular secretion of p-aminohippurate (PAH), bolus i.v. injection and constant i.v. infusion of PAH were loaded to rabbits. Time courses of plasma concentration and urinary excretion rate were analyzed using compartment model with saturable rate process. Effects of sulfamethizole (SMZ) constant infusion and bolus injection on PAH renal excretion were also examined. Multi-compartment model for concurrent disposition of PAH and SMZ is presented. Excretory processes are composed of non-saturable filtration, saturable secretion which is subject to mutual inhibition, and reabsorption.