文章基本信息

标题：BIOCHEMICAL STUDY ON SPONTANEOUS THYMOMA RATS WITH MOTOR DYSFUNCTION
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作者：FUMINORI KATO ; MINORU WATANABE
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1983
卷号：6
期号：4
页码：275-279
DOI：10.1248/bpb1978.6.275
出版社：The Pharmaceutical Society of Japan
摘要：Spontaneous thymoma rats, Buffalo/Mna (B/Mna), in which nephrotic syndrom (NS) has recently been observed, have notable features in connection with muscle diseases ; they exhibit muscle fatigability and weakness. Some biochemical measurements used for diagnosis of muscle diseases and NS were performed in these rats. ACI strain served as a reference strain. Urinary creatinine level and serum enzyme activities such as CPK, aldolase, GOT and GPT in the B/Mna rats did not differ from those in the ACI rats. On the other hand, urinary creatine level, the ratio of urinary creatine to creatinine and serum total cholesterol level in the B/Mna rats were significantly greater than those in the ACI rats. B/Mna rats also showed proteinuria and hypoalbuminemia. These results indicate the possibility of some pathological change of skeletal muscles which may result at least partially from abnormal lipid metabolism and hypoproteinemia as a consequence of NS, differing from the typical muscular dystrophy.
关键词：thymoma