文章基本信息

标题：COMPARISON OF EFFECTS OF SMOOTH MUSCLE RELAXING DRUGS IN INTESTINAL SMOOTH MUSCLE OF GUINEA PIG
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作者：TEIICHI MUKAI
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1983
卷号：6
期号：5
页码：301-308
DOI：10.1248/bpb1978.6.301
出版社：The Pharmaceutical Society of Japan
摘要：Effects of smooth muscle relaxants on histamine-, Ba²⁺-and Ca²⁺-induced contractions, or on electrical activities were examined in the longitudinal smooth muscle of guineapig ileum or taenia coli, respectively. Papaverine, D-600 and diltiazem effectively inhibited the Ca²⁺ responses and the tonic components of the histamine and Ba²⁺ responses. Especially, D-600 and diltiazem depressed the Ca²⁺ responses in much lower concentrations than papaverine and theophylline. In contrast, benactyzine and etomidoline were not specific antagonists against the Ca²⁺ responses, and they were effective inhibitory agents on the phasic responses to histamine and Ba²⁺. Nitroprusside failed to reduce the three types of contractions effectively. These results suggest that these seven relaxants can be divided into four types. Influence of those relaxants on spontaneously-and Ba²⁺-evoked electrical activities are compatible with the above differentiation. The four types of relaxants used in this study seem to exert their actions on smooth muscle in different way. Nitroprusside, however, is not a potent relaxant against contractions of the intestinal smooth muscles.
关键词：nitroprusside