文章基本信息

标题：INDUCTION OF LIVER MICROSOMAL 2-HYDROXYLATION OF ESTRADIOL 17-SULFATE BY PHENOBARBITAL IN MALE RAT
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作者：KAZUHIRO WATANABE ; ITSUO YOSHIZAWA
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1983
卷号：6
期号：6
页码：438-440
DOI：10.1248/bpb1978.6.438
出版社：The Pharmaceutical Society of Japan
摘要：Estradiol 17-sulfate 2-hydroxylase activity was measured in liver microsomes of 7-to 8-weeks-old Wistar male rats. Phenobarbital (80 mg/kg, daily for 4 d) injected intraperitoneally caused 30% increase of the enzyme activity and 160% increase of the microsomal cytochrome P-450 content. Treatment of rats with 3-methylcholanthrene (40 mg/kg, daily for 4 d) injected intraperitoneally caused no induction effect on 2-hydroxylase activity, but P-450 content was increased by 113%. Both the P-450 content and the enzyme activity were reduced to about half of the control, when the animals were injected subcutaneously with cobaltous chloride (30 mg/kg, daily for 2 d).
关键词：phenobarbital-induced hydroxylation