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标题：PROTECTIVE MECHANISM OF β-CYCLODEXIRIN FOR THE HEMOLYSIS INDUCED WITH PHENOTHIAZINE NEUROLEPTICS IN VITRO
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作者：TETSUMI IRIE ; MIKI SUNADA ; MASAKI OTAGIRI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1983
卷号：6
期号：6
页码：408-414
DOI：10.1248/bpb1978.6.408
出版社：The Pharmaceutical Society of Japan
摘要：β-Cyclodextrin (β-CyD) was found to protect the human erythrocytes from the hemolysis induced with ten phenothiazine neuroleptics in isotonic solution. The hemolytic activities of the phenothiazine-β-CyD systems appeared to depend upon the free phenothiazine concentration, suggesting that the complexed form of phenothiazines is essentially inactive to cause hemolysis. The binding abilities and surface activities of the complexed form of phenothiazines were much smaller than those of free phenothiazines. These results indicate that the protective effect of β-CyD may be due to the decrease in the effective hemolytic concentration of phenothiazines by inclusion complexation rather than the stabilizing effect of β-CyD on the erythrocyte membrane.
关键词：stability constant