文章基本信息

标题：DETERIORATION OF SPINAL REFLEX IN QUAILS ORALLY INGESTING CLIOQUINOL
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作者：SHINICHI MORISHITA ; MASAYOSHI GOTO ; HIDEOMI FUKUDA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1985
卷号：8
期号：9
页码：751-756
DOI：10.1248/bpb1978.8.751
出版社：The Pharmaceutical Society of Japan
摘要：Ataxia occurred in quails on long-term oral ingestion of clioquinol (CQ). Crossed extensor reflexes and spinal reflex potentials in the normal and the treated quails were recorded. The incidence of these reflexes was reduced in quails given CQ. As long as the spinal reflexes were detected, there were no prominent differences in the profiles of the reflex potentials between the normal groups and those with ataxia. Augmentation of the reflex potentials by strychnine in the treated group was more extensive than that in the normal group. The mechanisms of action by which CQ induces ataxia are discussed.
关键词：ataxia