文章基本信息

标题：INHIBITORY ACTION OF TAURINE ON MOTONEURON OF FROG SPINAL CORD
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作者：MICHIO KURACHI ; HIRONAKA AIHARA
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1985
卷号：8
期号：9
页码：733-737
DOI：10.1248/bpb1978.8.733
出版社：The Pharmaceutical Society of Japan
摘要：Using the sucrose gap method, the effect of taurine on the spinal cord of the bullfrog was investigated. Taurine inhibited the spontaneous potential and the ventral root reflex potential elicited by the stimulation of the dorsal root. The excitability of motoneuron did not necessarily diminish following taurine application. Taurine inhibited the responses induced by excitatory neurotransmitter candidates such as, glutamate and substance P, in a concentration dependent manner in the preparation, where the neurotransmission was abolished by Ca²⁺-deprivation and/or Mg²⁺-supplement. From these results, the depressant action of taurine on the electrical activities in the frog spinal cord may be interpreted, in part, by the inhibition of the response evoked by excitatory transmitter at postsynaptic site.
关键词：motoneuron