文章基本信息

标题：INTERACTION OF TETRACHLOROBIPHENYLS WITH ISOLATED RAT LIVER MITOCHONDRIA
本地全文：下载
作者：YOSHIMASA NISHIHARA ; LARREYW. ROBERTSON ; FRANZ OESCH 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1985
卷号：8
期号：9
页码：726-732
DOI：10.1248/bpb1978.8.726
出版社：The Pharmaceutical Society of Japan
摘要：A comparative study of the effects of tetrachlorobiphenyls (TCBs) on the succinate-supported respirations of rat liver mitochondria was made, and some differences in effects caused by the different chlorine positions of the biphenyl rings were clarified. The inhibitory actions of 2, 3, 2', 3'-, 2, 4, 2', 4'-, and 2, 5, 2', 5'-TCBs on both state 3 and uncouplerstimulated respirations were potent, while those induced by 2, 6, 2', 6'-, and 3, 4, 3', 4'-TCBs were weak. 2, 3, 2', 3'-, 2, 4, 2', 4'-, 2, 5, 2', 5'-, and 2, 6, 2', 6'-TCBs stimulated state 4 respiration, but 3, 4, 3', 4'-TCB had very little effect on this respiration. The latent adenosine triphosphatase activity was stimulated by 2, 3, 2', 3'-, 2, 4, 2', 4'-, and 2, 5, 2', 5'-TCBs, but 2, 6, 2', 6'-, and 3, 4, 3', 4'-TCBs had no effects. The relationship between these effects and chemical structure of TCBs is discussed.
关键词：rat liver mitochondria