文章基本信息

标题：KINETICS OF BACTERICIDAL ACTIVITY OF AMINOGLYCOSIDES DURING DYNAMIC DILUTION
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作者：YASUKO NAKAMURA ; MARIKO IKEDA ; RYUICHIRO NISHIGAKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1985
卷号：8
期号：9
页码：695-700
DOI：10.1248/bpb1978.8.695
出版社：The Pharmaceutical Society of Japan
摘要：The time courses for viable microorganism count after addition of aminoglycosides were investigated in exponentially decreasing concentrations in in vitro using a continuous flow culture system. When aminoglycosides were added to the incubation medium containing Escherichia coli, the growth rate began to decrease after a lag phase and recovered gradually after the concentration fell below its effective level. To simulate this time course, the following equation including the retardation function was proposed ; [numerical formula] where N is the number of viables, k_o is the generation rate constant, k_d is the dilution rate constant, P_c is the bactericidal coefficient per unit concentration characteristic to the individual antibiotic, k_r is the reciprocal of the retardation time and C_o is the initial concentration of the antibiotic. P_c and k_r were calculated using the nonlinear least square method and the calculated time course agreed with the observed experimental data indicating the appropriateness of this equation. P_c has a negative relationship to the minimum inhibitory concentration for six aminoglycosides studied, kanamycin, amikacin, kanamycin B, tobramycin, dibekacin and habekacin. The values of k_r ranged between 3.12×10^-2 to 6.40×10^-2 min^-1 and are thought to correlate with the mechanism of antibiotic actions.
关键词：habekacin