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标题：TRIMETHADIONE TOLERANCE TEST FOR EVALUATION OF FUNCTIONAL RESERVE OF THE LIVER IN PATIENTS WITH LIVER CIRRHOSIS AND ESOPHAGEAL VARICES
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作者：EINOSUKE TANAKA ; AKIO ISHIKAWA ; ATSUSHI ONO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1986
卷号：9
期号：3
页码：297-302
DOI：10.1248/bpb1978.9.297
出版社：The Pharmaceutical Society of Japan
摘要：Dimethadione (DMO)/trimerhadione (TMO) ratios in serum after oral administration of TMO were investigated in 15 normal subjects and in 20 patients with cirrhosis and esophageal varices. Severe impairment of liver function was associated with a decrease in total cholesterol, total protein and plasma albumin, or an increase in total bilirubin, serum glutamic oxaloacetic transaminsase, serum glutamic pyruvic transaminase, serum γ-glutamyl transpeptidase and indocyanine green retention rate (ICG R₁₅). Serum concentration ratios of DMO to TMO at 2 or 4 h after oral administration of TMO in patients were significantly decreased by 67 or 66%, respectively, compared to normal subjects. DMO/TMO ratios at 2 or 4 h following oral administration of TMO were well correlated with the liver function parameters (plasma albumin r=0.758 at 2 h, r=0.776 at 4 h ; total protein r=0.613 at 2 h, r=0.619 at 4 h ; ICG R ₁₅ r=-0.683 at 2 h, r=-0.746 at 4 h, in patients only ; cholinesterase r=0.873 at 2 h, r=0.908 at 4 h) as well as with pharmacokinetic parameters (total body clearance r=0.794 at 2 h, r=0.786 at 4 h) in both the normal subjects and the patients. It suggests that the DMO/TMO ratio obtained in a single blood sample collected after oral administration of TMO might provide a useful measure for function hepatic reserve.
关键词：drug metabolizing capacity