文章基本信息

标题：STRUCTURE-ACTIVITY RELATIONSHIP OF CARDIAC STEROIDS HAVING A DOUBLY LINKED SUGAR AND RELATED COMPOUNDS FOR THE INHIBITION OF Na+, K+-ADENOSINE TRIPHOSPHATASE
本地全文：下载
作者：KAZUTAKE SHIMADA ; NAOYUKI ISHII ; KAZUO OHISHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1986
卷号：9
期号：9
页码：755-759
DOI：10.1248/bpb1978.9.755
出版社：The Pharmaceutical Society of Japan
摘要：Forty-three different cardiac steroids having a doubly linked sugar and related compounds were tested for inhibition of Na⁺, K⁺-adenosine triphosphatase from guinea pig heart, and the structure-activity relationship has been discussed. The doubly linked glycosides showed higher activities than the respective genins. The inhibitory activities of these compounds were also dependent upon the presence of ring C substituents. The bufadienolide rhamnosides exhibited greater than three times the inhibitory activity of the parent genin, while the glucosyl residue exerted no significant activity.
关键词：structure-activity relationship