文章基本信息

标题：THREE-COMPARTMENT OPEN MODEL ANALYSIS OF MICRONOMICIN IN MAN
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作者：MAKOTO WATANABE ; NOBUYOSHI KANENIWA ; MITSUO MATSUMOTO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1986
卷号：9
期号：10
页码：783-786
DOI：10.1248/bpb1978.9.783
出版社：The Pharmaceutical Society of Japan
摘要：The pharmacokinetics of micronomicin (MCR) as a model drug of aminoglycoside antibiotics (AGs) was studied in man by applying our results previously obtained in rats. Three-compartment open model analysis of combined serum and total body store (T. B. S.) data obtained from multiple dosing in man was done using a non-linear least-squares regression program MULTI. We found large individual variations of MCR disposition in man and these variations did not appear within the serum cocentration range measurable with conventional assay methods. This finding suggests that the disposition of AGs, included MCR, cannot be estimated by only plasma or serum level analyses. We conclude that the therapeutic drug monitoring of AGs by using T. B. S. data analysis should be an effective method for controlling therapy with AGs in the clinical setting.
关键词：therapeutic drug monitoring