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标题：IN VITRO DEMONSTRATION OF DECREASED GLUCOSE OXIDATION IN BRAIN OF EXPERIMENTALLY DIABETIC RAT AND RECOVERY BY INSULIN
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作者：IKUYO SHIMA ; SHIGEKO KANAGUCHI ; SADAHIKO ISHIBASHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1979
卷号：2
期号：2
页码：74-77
DOI：10.1248/bpb1978.2.74
出版社：The Pharmaceutical Society of Japan
摘要：In the course of studies on glucose metabolism in the brain under the condition with excessive supply of glucose, ¹⁴CO₂ production from glucose-¹⁴C was examined by incubating the homogenate of the brain from control and streptozotocin-diabetic rats. The production was markedly decreased in the brain homogenate of the diabetic rats as compared with that of control rats. Administration of insulin in the diabetic rats restored the glucose oxidation activity to the control level, but about 30 min was necessary for the restoration. No difference was found between glucose-1-¹⁴C and glucose-6-¹⁴C in the change in ¹⁴CO₂ production by the brain homogenate from diabetic rats before and after insulin treatment.
关键词：streptozotocin