文章基本信息

标题：INTERFERON INDUCING ACTIVITY OF A 2'-MODIFIED DOUBLESTRANDED COMPLEX, POLY (2'-AZIDO-2'-DEOXYINOSINIC ACID) POLY (CYTIDYLIC ACID)
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作者：ERIK DE CLERCO ; TOSHIKAZU FUKUI ; NOBUKO KAKIUCHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1978
卷号：1
期号：1
页码：62-65
DOI：10.1248/bpb1978.1.62
出版社：The Pharmaceutical Society of Japan
摘要：Although the presence of free 2'-hydroxyl groups in both strands of a double-stranded RNA complex has been recognized as one of the major requisites for the interferon inducing activity of double-stranded RNAs, we have found a particular analog of (I)_n·(C)_n, in which the 2'-hydroxyls of the purine strand were replaced by azido groups [(dIz)_n·(C)_n], to be exquisitely effective in inducing interferon. Various other 2'-azido analogs, i.e. (dIz)_n·(brC)_n, (I)_n·(dCz)_n, (dAz)_n·(U)_n, (dAz)_n·(rT)_n and (dAz)_n·(dUz)_n were inactive as inducers of interferon. Thus we come to the conclusion that the interferon inducing system recognizes total threedimensional conformation of the double-stranded RNA.
关键词：human skin fibroblast cells