文章基本信息

标题：ENHANCED INTESTINAL PERMEABILITY TO MACROMOLECULES. I. EFFECT OF MONOOLEIN-BILE SALTS MIXED MICELLES ON THE SMALL INTESTINAL ABSORPTION OF HEPARIN
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作者：YUJI TOKUNAGA ; SHOZO MURANISHI ; HITOSHI SEZAKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1978
卷号：1
期号：1
页码：28-38
DOI：10.1248/bpb1978.1.28
出版社：The Pharmaceutical Society of Japan
摘要：The effect of monoolein-bile salts, sodium glycocholate and sodium taurocholate, mixed micellar solutions on the intestinal absorption of heparin was investigated using the in situ closed loop of the rats. It was observed that these mixed micellar solutions extremely enhanced the absorption of heparin and that the mixed micellar solution prepared with distilled water facilitated the intestinal absorption of heparin more markedly than that prepared with pH 6.5 phosphate buffer solution. This difference between mixed micellar distilled water solution and mixed micellar buffer solution was studied by ultrafiltration, pretreatment with the micellar and mixed micellar solutions, and gut exsorption. Enhanced permeability is discussed from the standpoints of intraluminal interaction between the mixed micelles and heparin molecules, and an alternation in the permeability of the mucosal membrane.
关键词：safe adjuvant