文章基本信息

标题：STIMULATORY EFFECT OF CYANIDE ON ANILINE p-HYDROXYLATION IN RAT LIVER MICROSOMES
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作者：MITSUKAZU KITADA ; TETSUYA KAMATAKI ; HARUO KITAGAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1978
卷号：1
期号：2
页码：74-80
DOI：10.1248/bpb1978.1.74
出版社：The Pharmaceutical Society of Japan
摘要：Enhancement of aniline hydroxylation was observed by the addition of cyanide in rat liver microsomes. The enhancing effect of cyanide on aniline hydroxylation activity was also observed in rabbit liver microsomes, but not in guinea pig liver microsomes. Aniline stimulated the reoxidation of reduced nicotinamide adenine dinucleotide (NADH)-reduced cytochrome b₅. The stimulation of cytochrome b₅ reoxidation by aniline was most remarkable in liver microsomes from desaturase-induced rats followed by that from fed and fasted rats. The increment in cytochrome b₅ reoxidation by aniline in all groups of rats was inhibited by the simultaneous addition of cyanide, However, the stimulatory effect of cyanide on aniline hydroxylation in fasted rat was not different from that observed in desaturase-induced rat. In addition, the effect of cyanide on aniline hydroxylation was suggested to be reversible.
关键词：rat.