文章基本信息

标题：EFFECT OF PREGNANT MARE SERUM GONADOTROPIN AND ESTRADIOL ON THE FORMATION OF 13, 14-DIHYDROPROSTAGLANDIN F2α IN RAT OVARY
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作者：NORIHISA INAZU ; HIROSHI KOGO ; YOSHIO AIZAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：7
页码：541-543
DOI：10.1248/bpb1978.4.541
出版社：The Pharmaceutical Society of Japan
摘要：Effects of pregnant mare serum gonadotropin (PMS) and estradiol on the formation of 13, 14-dihydroprostaglandin F_2α (13, 14H₂-PGF_2α) from prostaglandin F_2α (PGF_2α) and 13, 14-dihydro-15-ketoprostaglandin F_2α (15KD-PGF_2α) in the ovarian homogenate of rats were examined. PMS and estradiol were given to the rats (s.c.) on the first day of diestrus, and the ovaries were removed 24 hours after treatment with each hormone. PMS stimulated the formation of 13, 14H₂-PGF_2α from PGF_2α and 15KD-PGF_2α, and estradiol markedly inhibited the formation of 13, 14H₂-PGF_2α from PGF_2α and 15KD-PGF_2α. However, the formation of 15KD-PGF_2α from PGF_2α did not change with PMS and estradiol. These results indicate that 13, 14H₂-PGF_2α formed in rat ovary may play some important role in ovarian function and may be regulated by gonadotropins and ovarian steroids.
关键词：PGF2α catabolism