文章基本信息

标题：EXCRETION OF 1-HEXYLCARBAMOYL-5-FLUOROURACIL IN URINE OF MICE
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作者：MASAAKI IIGO ; ASAKO NAKAMURA ; KAZUO KURETANI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：7
页码：490-496
DOI：10.1248/bpb1978.4.490
出版社：The Pharmaceutical Society of Japan
摘要：Excretion and metabolites in urine and feces of mice after oral administration of 1-hexylcarbamoyl-5-fluorouracil-6-¹⁴C (¹⁴C-HCFU) or 5-fluorouracil-6-¹⁴C (¹⁴C-FU) were examined. After oral administration, about 90% of ¹⁴C-HCFU was excreted in urine within 48 h but not in feces. Major radioactive compounds in urine were 1-(3-carboxypropylcarbamoyl)-5-fluorouracil (CPRFU), FU, 5, 6-dihydro-5-fluorouracil (DHFU) and α-fluoro-β-alanine (FBAL). Excretion ratio of these metabolites within 48 h was 13.5, 32.5, 20.2 and 23.9%, respectively, CPRFU and FU were rapidly excreted in urine after ¹⁴C-HCFU administration followed by DHFU and FBAL. Excretion of the latter two degradation products of FU was slower. On the other hand, major metabolites in urine after ¹⁴C-FU administration were DHFU and FBAL, but intact FU was slightly excreted. Excretion ratio of FU, DHFU and FBAL within 48 h was 4.8, 58.1 and 28.2%, respectively.
关键词：oral administration