文章基本信息

标题：A SIMPLE METHOD TO DETERMINE THE RATIO OF CARDIAC TO VASCULAR β-RECEPTOR BLOCKADE IN THE RAT IN VIVO
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作者：YOSHITAKA KUDO ; HIROFUMI SOKABE ; JOHNE. ZEHR 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：7
页码：475-482
DOI：10.1248/bpb1978.4.475
出版社：The Pharmaceutical Society of Japan
摘要：We have devised a simple method to determine the ratios of cardiac to vascular β-receptor blockage (C : V ratios) in normotensive rats anesthetized with pentobarbital, and applied it to six β-adrenergic blocking drugs (β-blockers). Mean blood pressure (BP) and heart rate (HR) were recorded. Isoproterenol (3 ng-100 μg/kg, i.v.) was cumulatively injected before and after the intravenous administration of β-blockers at two dose-levels. Thus shifts of the dose-response curves in BP and HR were observed. "In vivo pA₂" values were calculated in molar doses per kg by Schild plots. The C : V ratio was calculated as antilogarithm of the difference of the mean in vivo pA₂ value in HR from that in BP. Those of atenolol, bometolol, bunitrolol, pindolol, propranolol, and sotalol were 9.77, 8.13, 2.95, 1.38, 1.20, and 0.71, respectively.
关键词：anesthetized rat