文章基本信息

标题：THERAPY FOR UROLITHIASIS WITH HYDROXAMIC ACIDS. IV. PREVENTION OF INFECTED URINARY STONE FORMATION WITH N-(PIVALOYL) GLYCINOHYDROXAMIC ACID
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作者：MASARU SATOH ; KEIICHI MUNAKATA ; KYOSUKE KITOH 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：7
页码：469-474
DOI：10.1248/bpb1978.4.469
出版社：The Pharmaceutical Society of Japan
摘要：With the aim of finding a prospective therapeutic compound with a promising potential for the treatment of urolithiasis, we evaluated the effectiveness of a new potent inhibitor of urease, N-(pivaloyl) glycinohydroxamic acid. The present study revealed that N-(pivaloyl) glycinohydroxamic acid effectively inhibited the alkalinization of urine and the stone formation in vitro and in vivo, due to its strong inhibitory potency against the ureolytic activity of intact Proteus mirabilis. The possibility of the clinical application of this compound in the prevention of struvite stone formation caused by infection of urea-splitting bacteria awaits evaluation of the safety of this compound.
关键词：Proteus mirabilis