文章基本信息

标题：ANTIHYPERTENSIVE ACTIVITY OF BUCUMOLOL, A β-ADRENERGIC BLOCKING AGENT, IN SPONTANEOUSLY HYPERTENSIVE RATS
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作者：MASAAKI MIYAMOTO ; HIROYUKI KOIKE ; KATSUAKI ITO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：7
页码：455-460
DOI：10.1248/bpb1978.4.455
出版社：The Pharmaceutical Society of Japan
摘要：Effects of bucumolol, a β-adrenergic blocking agent, on blood pressure and the renin angiotensin system were studied in spontaneously hypertensive rats (SHR). The results were compared with those of propranolol at an equipotent does in β-adrenergic blocking activity. Bucumolol lowered blood pressure and decreased plasma renin concentraton (PRC) in both acute and long-term experiments. There was a significant correlation between percent changes in blood pressure and PRC following a single administration of bucumolol. Decrease in PRC persisted for the 6-week observation period despite the sustained reduction in blood pressure. On the other hand, propranolol did not lower blood pressure in acute experiment while it decreased renin release. These results suggest that inhibition of renin release is involved in the antihypertensive action of bucumolol.
关键词：plasma aldosterone concentration