文章基本信息

标题：A NEW VERSION OF MULTI (ELS) FOR EXTENDED NONLINEAR LEAST SQUARES
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作者：KIYOSHI YAMAOKA ; HISASHI TANAKA
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1987
卷号：10
期号：1
页码：26-34
DOI：10.1248/bpb1978.10.26
出版社：The Pharmaceutical Society of Japan
摘要：A new version of MULTI (ELS) written in BASIC was presented for population pharmacokinetics for microcomputers. The program is provided with four algorithms of extended nonlinear least squares (steepest descent method, quasi-Newton method with DFP formula, quasi-Newton method with BFGS formula and simplex method). Four transformations of parameters can be selected to impose constraints on the parameters (no constraint on a parameter. Pi=Qi², Pi=B+(A-B)·sin² (Qi) and Pi=B+(A-B)·exp (Qi)/(1+exp (Qi)), where Pi denotes a population mean parameter or variance of inter-and intraindividual variations, Qi is a intermediate parameter, A and B are lower and upper limits of Pi. The definition of a population model and the modifications for BASIC compiler in the new version of MULTI (ELS) are the same as in the old version.
关键词：parameter transformation